National Academy of Sciences | Proceedings of the National Academy of Sciences of the United States of America

Journal Club

Highlighting recently published papers selected by Academy members

Journal Club: Microglial protein trafficking could play a role in neurodegenerative disorders

Posted on July 16, 2018 by Jyoti Madhusoodanan

Neurodegenerative conditions such as Alzheimer’s disease (AD) or Parkinson’s are associated with a build-up of insoluble, toxic forms of proteins such as amyloid or tau in the brain. Normally, intracellular protein complexes known as retromers help with recycling and trafficking … Continue reading →

Journal Club: Researchers may’ve finally solved mystery of crater ray formation

Posted on July 13, 2018 by Adam Mann

Look carefully at the full moon and you’ll see bright skinny streaks extending from large lunar craters. These are ejecta rays, spoke-like lines that seem to shoot from the circular impact site, a vivid testament to ancient explosions. But scientists … Continue reading →

Journal Club: Mouse microbiome findings offer insights into why a high-fat, low-carb diet helps epileptic children

Posted on June 28, 2018 by Carolyn Beans

For nearly a century, doctors have found that a strict high-fat, low-carbohydrate diet can limit seizures in children with epilepsy when medications fail. But exactly how this ketogenic diet works has remained largely a mystery. Now, researchers at the University … Continue reading →

Journal Club: Proprioceptive neurons offer new insights into a “sixth sense”

Posted on June 25, 2018 by Jessica P. Johnson

Proprioception allows people to know the position of parts of the body without seeing them, enabling us to touch type, walk in the dark without falling over, or drive a car while looking at the road. Defects in this sensory … Continue reading →

Journal Club: Timed treatment fends off hardening of arteries in mice

Posted on June 15, 2018 by Charlotte Schubert

Timing is everything—including, possibly, when treating cardiovascular disease. By administering a drug-like compound in mice at a certain point during the circadian cycle, researchers were able to slow atherosclerosis while minimizing side effects, according to a recent study in Cell … Continue reading →

Journal Club: Diagnosing disease with smartphone cameras

Posted on May 25, 2018 by Carolyn Beans

Bioengineers at the University of Washington have devised a way to use smartphone cameras for imaging diagnostics, paving the way to test for afflictions such as influenza and sexually transmitted infections without costly equipment. The technique, presented this month in Analytical … Continue reading →

Journal Club: Damaged reefs get quieter, causing fewer fish to hear their way home

Posted on April 30, 2018 by Carolyn Beans

A healthy coral reef creates quite the underwater racket. Reef croakers croak, damselfish woop-woop-woop, and clown fish sound thuds like a woodpecker at a tree. But a new study reports that climate-change related disturbances can turn down the volume … Continue reading →

Journal Club: Horizontal gene transfer can boost fitness quickly, but the conditions matter

Posted on April 27, 2018 by Jessica P. Johnson

Horizontal gene transfer (HGT) is rampant in the bacterial community, as well as in some other members of the tree of life. Researchers have long known that HGT events can improve an organism’s ability to adapt to changing environments. What’s … Continue reading →

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Journal Club: Older zebra finch fathers produce young with shorter lifespans

Posted on April 5, 2018 by Carolyn Beans

Scientists have long observed that the offspring of younger parents tend to live longer than the offspring of older parents in many animal species, including humans. But this phenomenon, dubbed the “Lansing effect” for the first scientist who described it, … Continue reading →

Journal Club: Studies hint at how cholesterol and other molecules move through cells

Posted on March 27, 2018 by Charlotte Schubert

Four recent studies take a close look at how molecules cross the gap between membrane contacts within a cell, offering insights into crucial cellular activities. Three of the papers elucidate the transport of cholesterol; the fourth suggests that such contact … Continue reading →

Categories: Cell Biology | Journal Club | Tagged cholesterol, contact site, LAM protein, plasma membrane, StARkin domain, sterol | Leave a comment