Journal Club

Highlighting recently published papers selected by Academy members

Author Archives: Jyoti Madhusoodanan

Journal Club: Microglial protein trafficking could play a role in neurodegenerative disorders

Neurodegenerative conditions such as Alzheimer’s disease (AD) or Parkinson’s are associated with a build-up of insoluble, toxic forms of proteins such as amyloid or tau in the brain. Normally, intracellular protein complexes known as retromers help with recycling and trafficking … Continue reading

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Journal Club: Enzyme helps to speedily create a key chemical bond in the lab, suggesting synthetic chemistry applications 

With just a few chemical tweaks, cellular enzymes can turn some of the most common amino acids into unique compounds that possess antimicrobial or medicinal properties. But in the lab, it’s much harder to derive these molecules when using conventional … Continue reading

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Journal Club: Macrophages help regenerate ear parts in spiny mice

Salamander tails and fish fins are oft-cited examples of animals’ ability to regenerate a lost limb or organ. But one mammal—the African spiny mouse—has also emerged as a model of regenerative abilities. In a recent study, Ashley Seifert of the University … Continue reading

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Journal Club: ATP could help proteins dissolve in cells, prompting a rethink about its function and evolution

Adenosine triphosphate (ATP) is widely considered biology’s “energy currency”. A crucial player in cell function, it stores and releases energy for enzymatic reactions in its phosphate bonds. But cells typically hoard amounts of ATP several hundred-fold higher than that needed … Continue reading

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Journal Club: Virus-infected plants create buzz among bees

A bout of a viral infection can leave tomato plants stunted and their leaves sickly. But it might offer a surprising reproductive boost: infected plants release a different smell than healthy ones, and that unique aroma can draw more bees … Continue reading

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Journal Club: Removing an immune inhibitor helps protect against lethal fungal infections

Protecting cells from out-of-control immune reactions comes at a price: the same protein that quiets B and T cells to prevent autoimmune responses may also hinder the body’s fight against pathogens. Now researchers have found that in the case of … Continue reading

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Journal Club: Human genetics contributes to gut microbiome composition

Microbial communities in the human gut are formed at birth and shaped over time by a person’s diet, and other aspects of lifestyle and environment. Now scientists have confirmed that human genetic sequence polymorphisms also play a key role in … Continue reading

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