Journal Club

Highlighting recently published papers selected by Academy members

Category Archives: Cell Biology

Journal Club: Simple model reproduces patterns of toxic protein buildup across multiple neurodegenerative diseases

Posted on October 26, 2018 by Jessica P. Johnson

Fatal neurodegenerative diseases including Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS) begin as tiny pockets of misfolded proteins that evade the body’s normal detritus-removal systems. They spread throughout the brain and clog neural pathways. But exactly how these proteins propagate … Continue reading →

Journal Club: Bioengineers build a tiny heart ventricle to better understand heart disease and treatment

Posted on August 3, 2018 by Amber Dance

Bioengineer Kit Parker wants to build replacement hearts for children born with heart defects. Although that goal remains a long way off, Parker recently took a step in that direction by assembling a 1:250 scale model of the human left … Continue reading →

Categories: Cell Biology | Journal Club | Medical Sciences | Tagged arrhythmia, heart attack, heart defect, isoproterenol, stem cells, tissue engineering, ventricle | Leave a comment

Journal Club: Studies hint at how cholesterol and other molecules move through cells

Posted on March 27, 2018 by Charlotte Schubert

Four recent studies take a close look at how molecules cross the gap between membrane contacts within a cell, offering insights into crucial cellular activities. Three of the papers elucidate the transport of cholesterol; the fourth suggests that such contact … Continue reading →

Categories: Cell Biology | Journal Club | Tagged cholesterol, contact site, LAM protein, plasma membrane, StARkin domain, sterol | Leave a comment

Journal Club: Scientists culture human placenta cells in hopes of understanding pregnancy complications

Posted on February 1, 2018 by Carolyn Beans

A collection of human placental cells known as trophoblasts are responsible for much of what goes right in a healthy pregnancy. But growing and studying these cells in the lab has been a major challenge. Now, a team of Japanese … Continue reading →

Journal Club: Cells use waves to regulate mitosis, suggesting similar wave dynamics as myriad natural phenomena

Posted on December 18, 2017 by Carrie Arnold

Over the past decade, biologists have discovered an ever-increasing number of phenomena that exhibit wave-like behavior. Everything from the firing of neurons to the spread of a virus through a population can show a similar pattern: they emanate from … Continue reading →

Journal Club: Cellular context determines whether factor promotes or tamps down cancer

Posted on November 14, 2017 by Charlotte Schubert

Some cellular factors have an impressive multitude of roles. One prime example is LKB1 (Liver Kinase B1). It controls both cell metabolism and cell polarity, telling cells which end is which. It also appears to act as both a tumor … Continue reading →

Journal Club: Wheat’s molecular response to full sun exposure could suggest ways to increase yield

Posted on August 25, 2017 by Carrie Arnold

A recent study points to novel ways of improving crop yields and food production by elucidating how long it takes for wheat to return to full photosynthesis when making the transition from shade to sun exposure. The Green Revolution in … Continue reading →

Journal Club: Insights from 3-D images defy assumptions about how plant cells communicate

Posted on June 23, 2017 by Carolyn Beans

When plant cells communicate, plasmodesmata serve as crucial conduits. These channels cross cell walls, linking one cell to its neighbor. If a plant needs to grow larger or fight off a pathogen, molecular signals pass through plasmodesmata to keep cells … Continue reading →

Categories: Cell Biology | Journal Club | Plant Biology | Tagged Arabidopsis, cell communication, electron microscopy, plant cell, plasmodesmata | Leave a comment

Journal Club: Macrophages help regenerate ear parts in spiny mice

Posted on June 10, 2017 by Jyoti Madhusoodanan

Salamander tails and fish fins are oft-cited examples of animals’ ability to regenerate a lost limb or organ. But one mammal—the African spiny mouse—has also emerged as a model of regenerative abilities. In a recent study, Ashley Seifert of the University … Continue reading →

Journal Club: ATP could help proteins dissolve in cells, prompting a rethink about its function and evolution

Posted on May 27, 2017 by Jyoti Madhusoodanan

Adenosine triphosphate (ATP) is widely considered biology’s “energy currency”. A crucial player in cell function, it stores and releases energy for enzymatic reactions in its phosphate bonds. But cells typically hoard amounts of ATP several hundred-fold higher than that needed … Continue reading →

Categories: Biochemistry | Cell Biology | Journal Club | Tagged Alzheimer's disease, Amyotrophic lateral sclerosis, ATP, plaque | 1 Comment