Journal Club

Highlighting recently published papers selected by Academy members

Category Archives: Neuroscience

Journal Club: Sticky proteins play crucial role in tailoring synapses

The proteins that join neurons together at the synapse do more than just act like glue. Synaptic adhesion proteins are known to affect the activity of neurotransmitters, weaken or strengthen synaptic connections, or direct where synapses form. Faulty adhesion proteins … Continue reading

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Journal Club: Giving the brain something to do highlights the circuitry of smarts

Scientists conducting neuroimaging studies hope that their MRI scans will offer up patterns that predict traits related to intelligence, personality, disease, or even offer insights into a patient’s clinical symptoms or their chances of responding to a drug. But according … Continue reading

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Journal Club: Microglial protein trafficking could play a role in neurodegenerative disorders

Neurodegenerative conditions such as Alzheimer’s disease (AD) or Parkinson’s are associated with a build-up of insoluble, toxic forms of proteins such as amyloid or tau in the brain. Normally, intracellular protein complexes known as retromers help with recycling and trafficking … Continue reading

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Journal Club: Mouse microbiome findings offer insights into why a high-fat, low-carb diet helps epileptic children

For nearly a century, doctors have found that a strict high-fat, low-carbohydrate diet can limit seizures in children with epilepsy when medications fail. But exactly how this ketogenic diet works has remained largely a mystery. Now, researchers at the University … Continue reading

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Journal Club: Proprioceptive neurons offer new insights into a “sixth sense”

Proprioception allows people to know the position of parts of the body without seeing them, enabling us to touch type, walk in the dark without falling over, or drive a car while looking at the road. Defects in this sensory … Continue reading

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Journal Club: Fruit flies’ internal circadian clocks continually check the temperature

As a fruit fly sails from sunshine into a patch of shade, its temperature drops by 10 degrees F or so. Immediately, certain neurons in its brain spring into action, telling the fly’s circadian clock about the temperature change. By … Continue reading

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Journal Club: New clues in the mystery of the mechanism of general anesthetics

Anesthetics have been used in surgery since the mid-1800s, but their exact mechanisms of action continue to be the subject of intense investigation. Past studies have suggested they block neurotransmitter receptors postsynaptically. Now a new study, published January 9 in … Continue reading

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Journal Club: New technique lights up the connectome, tracking signals across neuronal populations

Neuroscientists still possess an incomplete understanding of how different neurons interface and communicate throughout the brain’s wiring diagram, called the connectome. In a recent eLife article, Caltech molecular neurobiologist Carlos Lois and colleagues introduce a new tool to screen for such … Continue reading

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Journal Club: Illuminating the neurons that help fruit fly larvae escape danger

Disturb fruit fly larvae with sharp jabs or intense heat and they’ll respond the same way every time. “They always roll two or three times, and then stop rolling and land away from the noxious thing,” says neuroscientist Kazuo Emoto … Continue reading

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Journal Club: New roles found for protein key to neurotransmission

  Scientists know many of the proteins that make neurotransmission possible, but they don’t have a handle on how all the pieces work together.  “As someone who has studied the synapse for a long time, I still find it frustrating … Continue reading

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