Journal Club

Highlighting recently published papers selected by Academy members

Category Archives: Uncategorized

Journal Club: Tumors create an acidic environment that helps them invade surrounding tissues

Posted on March 29, 2019 by Jessica P. Johnson

Cancer cells tend to turn their extracellular environment acidic, thus helping these rogue cells thrive while creating a hostile environment for normal ones. Acidosis promotes tumor growth, metastasis and drug resistance, while helping tumor cells evade the immune system. But … Continue reading →

Journal Club: Simple model reproduces patterns of toxic protein buildup across multiple neurodegenerative diseases

Posted on October 26, 2018 by Jessica P. Johnson

Fatal neurodegenerative diseases including Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS) begin as tiny pockets of misfolded proteins that evade the body’s normal detritus-removal systems. They spread throughout the brain and clog neural pathways. But exactly how these proteins propagate … Continue reading →

Journal Club: New screening method promises to reveal elusive cellular receptors for a range of pathogens

Posted on September 7, 2018 by Carolyn Beans

The surfaces of human cells are chock-full of proteins that help cells communicate with one another. Unfortunately, many viruses coopt these proteins, latching on in order to enter cells. By revealing which proteins are receptors for which viruses, researchers may … Continue reading →

Journal Club: Dogs can harbor evolving flu viruses, signaling potential future threat to humans

Posted on July 19, 2018 by Carolyn Beans

When scientists search for the origins of a novel influenza A outbreak, they often trace the virus back to birds or pigs. These animals act as reservoirs, hosts that allow diverse flu viruses to swap genome segments, evolving into new … Continue reading →

Journal Club: Researchers may’ve finally solved mystery of crater ray formation

Posted on July 13, 2018 by Adam Mann

Look carefully at the full moon and you’ll see bright skinny streaks extending from large lunar craters. These are ejecta rays, spoke-like lines that seem to shoot from the circular impact site, a vivid testament to ancient explosions. But scientists … Continue reading →

Journal Club: Horizontal gene transfer can boost fitness quickly, but the conditions matter

Posted on April 27, 2018 by Jessica P. Johnson

Horizontal gene transfer (HGT) is rampant in the bacterial community, as well as in some other members of the tree of life. Researchers have long known that HGT events can improve an organism’s ability to adapt to changing environments. What’s … Continue reading →

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Journal Club: Older zebra finch fathers produce young with shorter lifespans

Posted on April 5, 2018 by Carolyn Beans

Scientists have long observed that the offspring of younger parents tend to live longer than the offspring of older parents in many animal species, including humans. But this phenomenon, dubbed the “Lansing effect” for the first scientist who described it, … Continue reading →

Journal Club: Scientists culture human placenta cells in hopes of understanding pregnancy complications

Posted on February 1, 2018 by Carolyn Beans

A collection of human placental cells known as trophoblasts are responsible for much of what goes right in a healthy pregnancy. But growing and studying these cells in the lab has been a major challenge. Now, a team of Japanese … Continue reading →

Journal Club: In the mouse gut, a bacteria-killing virus evolves to attack a new strain

Posted on November 30, 2017 by Carolyn Beans

In scientists’ quest to understand how gut microbes affect human health, bacteria take center stage. But bacteriophages, the viruses that attack the bacteria, are often overlooked, says microbiologist Luisa De Sordi of the Institut Pasteur in France. “We keep an … Continue reading →

Journal Club: Fruit fly hybrids make poor foragers, offering insight into how species remain distinct

Posted on January 20, 2017 by Carolyn Beans

When one fruit fly species meets another, they sometimes interbreed. And yet despite this genetic mixing, distinct species still persist—over 2,000 of them. Evolutionary biologist Daniel Matute of the University of North Carolina at Chapel Hill is one of … Continue reading →