Journal Club

Highlighting recently published papers selected by Academy members

Tag Archives: neurodegenerative disease

Journal Club: Simple model reproduces patterns of toxic protein buildup across multiple neurodegenerative diseases

Fatal neurodegenerative diseases including Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS) begin as tiny pockets of misfolded proteins that evade the body’s normal detritus-removal systems. They spread throughout the brain and clog neural pathways. But exactly how these proteins propagate … Continue reading

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Journal Club: Microglial protein trafficking could play a role in neurodegenerative disorders

Neurodegenerative conditions such as Alzheimer’s disease (AD) or Parkinson’s are associated with a build-up of insoluble, toxic forms of proteins such as amyloid or tau in the brain. Normally, intracellular protein complexes known as retromers help with recycling and trafficking … Continue reading

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Journal Club: New roles found for protein key to neurotransmission

  Scientists know many of the proteins that make neurotransmission possible, but they don’t have a handle on how all the pieces work together.  “As someone who has studied the synapse for a long time, I still find it frustrating … Continue reading

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