Journal Club

Highlighting recently published papers selected by Academy members

Category Archives: Immunology

Journal Club: Zika virus causes eye problems, suggesting implications for diagnostics and transmission

A significant number of Zika patients experience problems with their eyes. Now scientists find that the Zika virus can infect every part of the eye in mice. Moreover, its RNA can be detected in teardrops, and samples from infected eyes … Continue reading

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Journal Club: Removing an immune inhibitor helps protect against lethal fungal infections

Protecting cells from out-of-control immune reactions comes at a price: the same protein that quiets B and T cells to prevent autoimmune responses may also hinder the body’s fight against pathogens. Now researchers have found that in the case of … Continue reading

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Journal Club: Low-calorie diets might improve effectiveness of cancer treatments

The old saying goes, “feed a cold, starve a fever”—now scientists might add, “starve a tumor.” In mice, a low-protein, low-calorie diet sensitizes breast cancer and melanoma cells to attack by the immune system, while prodding the immune system itself … Continue reading

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Journal Club: Mosquito saliva inflames immune system to spread viruses, suggesting possible interventions

The quick, piercing bite of a mosquito leaves behind a tiny amount of saliva under the skin of its prey. This saliva has been shown to have potent effects, such as numbing the pain of the bite and preventing blood … Continue reading

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Journal Club: T-cells transform, defying expectations and suggesting a new therapeutic avenue

Inflammation can help the human body fight off infections. If left unchecked, it can also lead to a variety of inflammatory disorders, such as gout and lupus. Now scientists find that in mice, a kind of immune cell that normally … Continue reading

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Skin’s immune memory lasts a lifetime

When a patch of skin becomes inflamed—due to an infection or irritation—immune cells flock to the site to fight off any pathogens. Now, scientists have discovered that cells lodged in the skin keep the memory of such an infection for … Continue reading

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Mice with human immune systems boon to malaria research

Plasmodium falciparum, the parasite that causes malaria infections in humans throughout sub-Saharan Africa and Southeast Asia, doesn’t have any effect on most mice. The parasite has a specific taste for mosquitos and humans and passes up the cells of other … Continue reading

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Controlling macrophage behavior via cell shape

Macrophages are immune cells that gobble intruders, renegades and debris. Now researchers discover cell shape can help control macrophages — for instance, elongating them promotes behavior that enhances healing. These findings, detailed in the Proceedings of the National Academy of … Continue reading

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Testing vaccine efficacy on a chip

If you are expecting to live past 40, or are there already, chances are you have modern vaccines, in part, to thank. Since Edward Jenner introduced the idea of vaccination in the 18th century vaccines have become the most effective … Continue reading

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Some fish skin has an immune response like the gut

The skin of most vertebrates is infiltrated by immune cells, but little is known about the origin and behavior of these cells. Now researchers find that certain immune cells in fish skin respond much like the immune cells found in … Continue reading

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Virus to blame for cancers in Los Angeles Zoo koalas

In zoos around the world, and throughout Australia’s eucalyptus groves, koalas are dying of cancer. More than half of all captive koalas eventually die of leukemia or lymphoma, although some zoos see more of the blood cancers than others. Now, … Continue reading

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