Journal Club

Highlighting recent, timely papers selected by Academy member labs

Category Archives: Medical Sciences

Easily made, robust chemical reagents could be game changer for developing world science

Enzymes and other chemical reagents are crucial for all sorts of life sciences research. Typically, they’re produced in industrial processes by modified bacteria; then they’re extracted and purified. But scientists in many parts of the world struggle to access such … Continue reading

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Opinion: How to ensure regulations don’t stymie much-needed COVID-19 point-of-care testing

Clare Rocka,1 and Jonathan Zenilmana a Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287.   The coronavirus disease 2019 (COVID-19) pandemic has raged for more than a year in the United States, upending … Continue reading

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Mutations in metabolic genes can cause antibiotic resistance

A recent study in Science reveals a novel avenue by which genetic changes make bacteria resistant to drugs: mutations in genes involved in cellular metabolism, including some that convert food into energy. “The genes were known; their involvement in metabolism … Continue reading

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A cellular and genetic atlas of the lung offers insights into disease and development

Explorers need maps. That’s as true for hikers blazing trails as it is for molecular biologists striving to cure disease. A new atlas of the lungs, recently published in Nature, is the most comprehensive map ever of that vital organ. … Continue reading

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Study finds clues to Alzheimer’s disease onset in the aging female brain  

In the United States, women make up nearly two-thirds of all diagnosed cases of Alzheimer’s disease. On average, women live about 5 years longer than men, but that life expectancy discrepancy doesn’t likely account for such a large, sex-skewed prevalence … Continue reading

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Insights into heat shock protein machinery could point to interventions for neurodegenerative disease

Heat shock proteins perform a range of functions related to protein quality control. Among them: breaking down dangerous protein aggregates called amyloid fibers. The buildup of certain amyloids has been linked to neurodegenerative disease. But the exact mechanism by which … Continue reading

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PREVIEW News Feature: To counter the pandemic, clinicians bank on repurposed drugs

Teams are pursuing a dizzying array of therapeutic strategies to stymie COVID-19. It’s not yet clear which approach, or combination of approaches, will work best. *Editor’s Note: We’re providing a preview of this content due to the urgent and rapidly … Continue reading

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Fluid dynamics work hints at whether spoken word can spread COVID-19

As of April 3, the Centers for Disease Control and Prevention (CDC) is advising that everyone—sick or healthy—wear masks to prevent the spread of COVID-19. Recent research on how fluids travel from our respiratory tracts when we sneeze, speak, or … Continue reading

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PREVIEW Inner Workings: Molecular biologists offer “wartime service” in the effort to test for COVID-19

*Editor’s Note: We’re providing a preview of this content due to the urgent and rapidly unfolding events surrounding the novel coronavirus pandemic. An updated version will appear in PNAS in the coming weeks. As COVID-19 spreads, communities across the United … Continue reading

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Mouse gut bacteria cure rotavirus infection, pointing to treatment for humans

Despite available vaccines, over 200,000 children die annually from severe diarrhea cause by rotavirus, which infects intestinal cells. A recently published study, facilitated by a research team’s lucky break, suggests bacteria in the mouse gut microbiome could actually help prevent … Continue reading

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Hydrogel uses biology and light to release proteins on demand, advancing hopes for synthetic tissues

A wiggly cylinder of protein, hydrogel, and human cells, about the size of a wristwatch battery, could one day serve as a building block for synthetic tissues. The implications could be big for biological research and even organ transplants, according … Continue reading

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