Journal Club

Highlighting recently published papers selected by Academy members

Category Archives: Medical Sciences

Journal Club: In big advance for lab-grown organs, 3-D printing better replicates tissue complexity

The lung is a feathery web of blood vessels and air sacs that branch closely together, but never touch. They’re nestled near enough that oxygen can diffuse into the bloodstream, but far enough that blood and air flow through separate … Continue reading

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Journal Club: Newly discovered ion channel gene promises disease insights

The molecular identity and precise function of a commonly expressed cell-membrane chloride channel has long been a mystery. A recent study in Science uncovers the gene responsible for the channel, potentially shedding light on its role in the body. Researchers … Continue reading

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Journal Club: Tumors create an acidic environment that helps them invade surrounding tissues

Cancer cells tend to turn their extracellular environment acidic, thus helping these rogue cells thrive while creating a hostile environment for normal ones. Acidosis promotes tumor growth, metastasis and drug resistance, while helping tumor cells evade the immune system. But … Continue reading

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Journal Club: Ion channel puts the squeeze on blood vessels, affecting blood pressure

Blood pressure is exquisitely regulated to respond to our physiological state. Stress raises blood pressure. Simply stand up, and the arteries constrict to maintain pressure. New findings in mice show how a protein called PKD2 helps regulate blood pressure by … Continue reading

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Journal Club: Being less infectious pays off for lung pathogen

The human body is home to millions of commensal microbes, some of which—given the right circumstances—can cause disease. One such microbe, known as nontypeable Haemophilus influenzae (NTHi), infects the lungs of patients with chronic obstructive pulmonary disease (COPD), a condition that … Continue reading

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Journal Club: Drug-resistant microbes could threaten future global economy, low income countries in particular

Antimicrobial resistance is not only a major public health threat, but also an economic one, according to researchers at The World Bank. Their new study, published in the journal World Development, suggests that an increase in drug-resistant microbes could cause … Continue reading

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Journal Club: Bioengineers build a tiny heart ventricle to better understand heart disease and treatment

Bioengineer Kit Parker wants to build replacement hearts for children born with heart defects. Although that goal remains a long way off, Parker recently took a step in that direction by assembling a 1:250 scale model of the human left … Continue reading

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Journal Club: Microglial protein trafficking could play a role in neurodegenerative disorders

Neurodegenerative conditions such as Alzheimer’s disease (AD) or Parkinson’s are associated with a build-up of insoluble, toxic forms of proteins such as amyloid or tau in the brain. Normally, intracellular protein complexes known as retromers help with recycling and trafficking … Continue reading

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Journal Club: Timed treatment fends off hardening of arteries in mice

Timing is everything—including, possibly, when treating cardiovascular disease. By administering a drug-like compound in mice at a certain point during the circadian cycle, researchers were able to slow atherosclerosis while minimizing side effects, according to a recent study in Cell … Continue reading

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Journal Club: Diagnosing disease with smartphone cameras

Bioengineers at the University of Washington have devised a way to use smartphone cameras for imaging diagnostics, paving the way to test for afflictions such as influenza and sexually transmitted infections without costly equipment. The technique, presented this month in Analytical … Continue reading

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