A recent study in Science reveals a novel avenue by which genetic changes make bacteria resistant to drugs: mutations in genes involved in cellular metabolism, including some that convert food into energy. “The genes were known; their involvement in metabolism … Continue reading
Journal Club
Highlighting recent, timely papers selected by Academy member labs
Category Archives: Microbiology
Intensive agriculture changes the soil microbiome
California rice farms dot the Sacramento Valley, converting native swampland into flooded paddies. The farms change California’s landscape both above ground and below it. A recent study shows in detail how rice plants shape the soil microbiome into a distinctive … Continue reading
Mouse gut bacteria cure rotavirus infection, pointing to treatment for humans
Despite available vaccines, over 200,000 children die annually from severe diarrhea cause by rotavirus, which infects intestinal cells. A recently published study, facilitated by a research team’s lucky break, suggests bacteria in the mouse gut microbiome could actually help prevent … Continue reading
Journal Club: Amoeba have long-distance preference for certain bacteria, pointing to other cell-sensing insights
How does the microscopic amoeba track down prey in the vastness of the forest floor? Ample research on the soil amoeba Dicytostelium discoideum, affectionately called “Dicty” by researchers, has provided some clues. But the mechanisms behind long-distance sensing of bacterial … Continue reading
Journal Club: Being less infectious pays off for lung pathogen
The human body is home to millions of commensal microbes, some of which—given the right circumstances—can cause disease. One such microbe, known as nontypeable Haemophilus influenzae (NTHi), infects the lungs of patients with chronic obstructive pulmonary disease (COPD), a condition that … Continue reading
Journal Club: New screening method promises to reveal elusive cellular receptors for a range of pathogens
The surfaces of human cells are chock-full of proteins that help cells communicate with one another. Unfortunately, many viruses coopt these proteins, latching on in order to enter cells. By revealing which proteins are receptors for which viruses, researchers may … Continue reading
Journal Club: Drug-resistant microbes could threaten future global economy, low income countries in particular
Antimicrobial resistance is not only a major public health threat, but also an economic one, according to researchers at The World Bank. Their new study, published in the journal World Development, suggests that an increase in drug-resistant microbes could cause … Continue reading
Journal Club: Mouse microbiome findings offer insights into why a high-fat, low-carb diet helps epileptic children
For nearly a century, doctors have found that a strict high-fat, low-carbohydrate diet can limit seizures in children with epilepsy when medications fail. But exactly how this ketogenic diet works has remained largely a mystery. Now, researchers at the University … Continue reading
Journal Club: In the mouse gut, a bacteria-killing virus evolves to attack a new strain
In scientists’ quest to understand how gut microbes affect human health, bacteria take center stage. But bacteriophages, the viruses that attack the bacteria, are often overlooked, says microbiologist Luisa De Sordi of the Institut Pasteur in France. “We keep an … Continue reading
Journal Club: Twin study elucidates environmental, genetic contributions to mouth microbiome and oral health
Some of the mouth’s microbial communities may promote good health, while others contribute to cavities, gum disease, and possibly even heart disease. Now, scientists are learning more about how genetic and environmental factors influence the mouth’s microbial makeup, and how … Continue reading