Journal Club

Highlighting recent, timely papers selected by Academy member labs

Category Archives: Microbiology

Mutations in metabolic genes can cause antibiotic resistance

Posted on March 5, 2021 by Amy McDermott

A recent study in Science reveals a novel avenue by which genetic changes make bacteria resistant to drugs: mutations in genes involved in cellular metabolism, including some that convert food into energy. “The genes were known; their involvement in metabolism … Continue reading →

Host defenses signal Salmonella to hijack immune cells, spur disease

Posted on February 12, 2021 by Amy McDermott

Immune cells attack dangerous bacteria by engulfing them and then releasing a cascade of defense molecules. But some bacteria, known as intracellular pathogens, have evolved to survive this onslaught and replicate inside immune cells. The result can be Salmonella poisoning … Continue reading →

Categories: Immunology | Journal Club | Microbiology | Tagged macrophage, metabolism, metabolite, salmonella, Salmonella enterica serovar Typhimurium, succinate | Leave a comment

Intensive agriculture changes the soil microbiome

Posted on November 8, 2019 by Amy McDermott

California rice farms dot the Sacramento Valley, converting native swampland into flooded paddies. The farms change California’s landscape both above ground and below it. A recent study shows in detail how rice plants shape the soil microbiome into a distinctive … Continue reading →

Categories: Agriculture | Microbiology | Tagged agriculture, disease, microbiome, rice, soil | 1 Comment

Mouse gut bacteria cure rotavirus infection, pointing to treatment for humans

Posted on October 25, 2019 by Natasha Gilbert

Despite available vaccines, over 200,000 children die annually from severe diarrhea cause by rotavirus, which infects intestinal cells. A recently published study, facilitated by a research team’s lucky break, suggests bacteria in the mouse gut microbiome could actually help prevent … Continue reading →

Journal Club: Amoeba have long-distance preference for certain bacteria, pointing to other cell-sensing insights

Posted on January 29, 2019 by Jessica P. Johnson

How does the microscopic amoeba track down prey in the vastness of the forest floor? Ample research on the soil amoeba Dicytostelium discoideum, affectionately called “Dicty” by researchers, has provided some clues. But the mechanisms behind long-distance sensing of bacterial … Continue reading →

Journal Club: Being less infectious pays off for lung pathogen

Posted on October 21, 2018 by Jyoti Madhusoodanan

The human body is home to millions of commensal microbes, some of which—given the right circumstances—can cause disease. One such microbe, known as nontypeable Haemophilus influenzae (NTHi), infects the lungs of patients with chronic obstructive pulmonary disease (COPD), a condition that … Continue reading →

Journal Club: New screening method promises to reveal elusive cellular receptors for a range of pathogens

Posted on September 7, 2018 by Carolyn Beans

The surfaces of human cells are chock-full of proteins that help cells communicate with one another. Unfortunately, many viruses coopt these proteins, latching on in order to enter cells. By revealing which proteins are receptors for which viruses, researchers may … Continue reading →

Journal Club: Drug-resistant microbes could threaten future global economy, low income countries in particular

Posted on August 31, 2018 by Carolyn Beans

Antimicrobial resistance is not only a major public health threat, but also an economic one, according to researchers at The World Bank. Their new study, published in the journal World Development, suggests that an increase in drug-resistant microbes could cause … Continue reading →

Journal Club: Mouse microbiome findings offer insights into why a high-fat, low-carb diet helps epileptic children

Posted on June 28, 2018 by Carolyn Beans

For nearly a century, doctors have found that a strict high-fat, low-carbohydrate diet can limit seizures in children with epilepsy when medications fail. But exactly how this ketogenic diet works has remained largely a mystery. Now, researchers at the University … Continue reading →

Journal Club: In the mouse gut, a bacteria-killing virus evolves to attack a new strain

Posted on November 30, 2017 by Carolyn Beans

In scientists’ quest to understand how gut microbes affect human health, bacteria take center stage. But bacteriophages, the viruses that attack the bacteria, are often overlooked, says microbiologist Luisa De Sordi of the Institut Pasteur in France. “We keep an … Continue reading →

Journal Club: Twin study elucidates environmental, genetic contributions to mouth microbiome and oral health

Posted on September 23, 2017 by Helen Shen

Some of the mouth’s microbial communities may promote good health, while others contribute to cavities, gum disease, and possibly even heart disease. Now, scientists are learning more about how genetic and environmental factors influence the mouth’s microbial makeup, and how … Continue reading →