Tag Archives: metabolism

Mutations in metabolic genes can cause antibiotic resistance

Posted on March 5, 2021 by Amy McDermott

A recent study in Science reveals a novel avenue by which genetic changes make bacteria resistant to drugs: mutations in genes involved in cellular metabolism, including some that convert food into energy. “The genes were known; their involvement in metabolism … Continue reading →

Host defenses signal Salmonella to hijack immune cells, spur disease

Posted on February 12, 2021 by Amy McDermott

Immune cells attack dangerous bacteria by engulfing them and then releasing a cascade of defense molecules. But some bacteria, known as intracellular pathogens, have evolved to survive this onslaught and replicate inside immune cells. The result can be Salmonella poisoning … Continue reading →

Categories: Immunology | Journal Club | Microbiology | Tagged macrophage, metabolism, metabolite, salmonella, Salmonella enterica serovar Typhimurium, succinate | Leave a comment

Journal Club: Cellular context determines whether factor promotes or tamps down cancer

Posted on November 14, 2017 by Charlotte Schubert

Some cellular factors have an impressive multitude of roles. One prime example is LKB1 (Liver Kinase B1). It controls both cell metabolism and cell polarity, telling cells which end is which. It also appears to act as both a tumor … Continue reading →